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Agenda

The daily agenda is subject to change. We appreciate your patience.

Thursday, October 13, 2022

McNamara Alumni Center, University Hall

5:00 p.m. ? 6:30 p.m.
Registration opens at McNamara Alumni Center
 
6:00 p.m. ? 7:30 p.m.
Welcome Reception
 
7:30 p.m. ? 7:45 p.m.
Welcoming Statements ? Paul Robbins, Ph.D., Nathan LeBrasseur, Ph.D., M.S. and Laura Niedernhofer, M.D., Ph.D.
 
7:45 p.m. ? 8:45 p.m.
Keynote Address: Matt Kaeberlein, Ph.D.

Friday, October 14, 2022

Pinnacle Room ? Graduate Hotel

7:30 a.m. ? 9:00 a.m.
Registration opens on second floor of the Graduate Hotel
 
8:00 a.m. ? 9:00 a.m.
Breakfast and Coffee
 
Session 1: Clinical Studies for Aging
Chairs: George Kuchel, M.D. and Lene Rasmussen, Ph.D.
9:00 a.m. ? 9:20 a.m.
Sundeep Khosla, M.D.
9:20 a.m. ? 9:40 a.m.
Folkert Kuipers, Ph.D.
9:40 a.m. ? 10:00 a.m.
Jamie Justice, Ph.D.
10:00 a.m. ? 10:20 a.m.
Derek Mann, Ph.D.
 
10:20 a.m. ? 10:45 a.m.
Coffee Break
 
Session 2: Biomarkers for assessment of biology of aging
Nathan LeBrasseur, Ph.D., M.S. and Steve Cummings, M.D.
10:45 a.m. ? 11:05 a.m.
Xiao Dong, Ph.D.
11:05 a.m. ? 11:25 a.m.
Marissa Schafer, Ph.D.
11:25 a.m. ? 11:45 a.m.
Vadim N. Gladyshev, Ph.D.
11:45 a.m. ? 12:05 p.m.
Pinchas Cohen, M.D.
 
12:05 p.m. ? 1:15 p.m.
Lunch
 
Session 3: Promising translational projects: identification of new therapeutics and therapeutic targets
Chairs: Marco Demaria, Ph.D. and Dave Bernlohr, Ph.D.
1:15 p.m. ? 1:35 p.m.
Morten Scheibye-Knudsen, M.D., Ph.D.
1:35 p.m. ? 1:55 p.m.
Stefan Tullius, M.D., Ph.D.
1:55 p.m. ? 2:15 p.m.
Satomi Miwa, Ph.D.
2:15 p.m. ? 2:35 p.m.
Yousin Suh, Ph.D.
 
2:35 p.m. ? 3:00 p.m.
Coffee Break
 
Session 4: Advances in the basic biology of aging
Chairs: Satomi Miwa, Ph.D. and Tamara Tchkonia, Ph.D., M.S.
3:00 p.m. ? 3:20 p.m.
Rob Henning, M.D.
3:20 p.m. ? 3:40 p.m.
Matt Gill, Ph.D.
3:40 p.m. ? 4:00 p.m.
Diana Jurk, Ph.D.
4:00 p.m. ? 4:20 p.m.
Simon Bekker-Jensen, Ph.D.
 
4:30 p.m. ? 6:30 p.m.
Poster Session
 
6:30 p.m. ? 7:00 p.m.
Reception ? Meridian Foyer
 
7:00 p.m.
Gala Dinner ? Meridian Ballroom

Saturday, October 15, 2022

Pinnacle Room ? Graduate Hotel

8:00 a.m. ? 9:00 a.m.
Breakfast and Coffee
 
Session 5: Promising translational projects: New indications and approaches
Chairs: Folkert Kuipers, Ph.D. and Diana Jurk, Ph.D.
9:00 a.m. ? 9:20 a.m.
Marco Demaria, Ph.D.
9:20 a.m. ? 9:40 a.m.
Christina Camell, Ph.D.
9:40 a.m. ? 10:00 a.m.
Nuno Raimundo, Ph.D.
10:00 a.m. ? 10:20 a.m.
Vesna Garovic, M.D., Ph.D.
 
10:20 a.m. ? 10:45 a.m.
Coffee Break
 
Student/Postdoc Session ? Selected from Abstracts
Chairs: Vinal Menon, Ph.D. and Stella Victorelli, Ph.D.
10:45 a.m. ? 11:00 a.m.
Talk 1 Helene Martini, Pharm.D.
11:00 a.m. ? 11:15 a.m.
Talk 2 Davis Englund, Ph.D.
11:15 a.m. ? 11:30 a.m.
Talk 3 Ines Sturmlechner, Ph.D.
11:30 a.m. ? 11:45 a.m.
Talk 4 Karina S. Kanamori Mendes, M.D.
11:45 a.m. ? 12:00 p.m.
Talk 5 Elizabeth L. Thompson, Ph.D.
12:00 p.m. ? 12:15 p.m.
Talk 6 Arbi Aghali, Ph.D.
 
12:20 p.m. ? 12:30 p.m.
Closing Remarks
 
12:30 p.m.
Lunch
Simon Bekker-Jensen
Simon Bekker-Jensen Headshot

Simon Bekker-Jensen has a PhD in Cancer Biology from the Technical University of Denmark and the Danish Cancer Research Centre. Prior to establishing his independent group within cellular stress signaling in 2016, he has 10 years of experience in research within the DNA damage response. Amongst others, he holds a Consolidator Grant from The European Research Council and is an EMBO Young Investigator.

Dave Bernlohr
Dave Bernlohr Headshot

The major research theme in the Bernlohr laboratory is the metabolic relationships between obesity and cellular senescence. The laboratory specifically examines macrophage-adipocyte crosstalk, lipid signaling, and the activation of the senescence program by oxidized lipids.

Christina Camell
Christina Camell Headshot

Dr. Christina Camell is an Assistant Professor at the Institute on the Biology of Aging and Metabolism and in the Department on Biochemistry, Molecular Biology, and Biophysics.

We investigate the immune response and the accumulation in inflammation during aging. We are specifically focused on metabolic, non-lymphoid tissues.

Pinchas Cohen
Pinchas Cohen Headshot

Dr. Cohen graduated in 1986 with highest honors from the Technion Medical School in Israel and trained at Stanford University. He held faculty positions at the University of Pennsylvania, and at UCLA where he led the Diabetes Research Center. In 2012 he was appointed as the Dean of the USC Leonard Davis School of Gerontology. He received numerous awards through his career, including a National Institute of Aging ?EUREKA?-Award and the NIH-Director-Transformative RO1-Grant. He also received the Glenn Award for Research in Biological Mechanisms of Aging and the AFAR Irving S. Wright Award of Distinction. He is the Cofounder of CohBar, a biotechnology company developing mitochondrial peptides for diseases of Aging. Dr. Cohen published over 350 papers in top scientific journals focusing on aging, cancer, diabetes, and the emerging science of microproteins and his h-index is 100.

Steven Cummings
Steven Cummings Headshot

Dr. Cummings received his training in Internal Medicine and Clinical Epidemiology at UCSF and is Professor of Medicine, Epidemiology and Biostatistics (emeritus) at the UCSF. He directs the San Francisco Coordinating Center affiliated with the California Pacific Medical Center Research Institute. He founded the Coordinating Center 40 years ago and led many of the major studies about treatments for osteoporosis and designed and led large studies about the biology of human aging. Dr. Cummings has published over 600 peer-reviewed publications, was elected to the National Academy of Medicine (formerly the IOM) in the National Academy of Sciences and honored with several international awards for his clinical research in osteoporosis and aging.

Dr. Cummings is the corresponding PI for the Study of Muscle Mobility and Aging (SOMMA), a cohort study of 879 people age 70+ designed to elucidate the biological predictors of loss of fitness and strength and mobility disability with aging. It uniquely includes muscle and fat biopsies, total body imaging, and extensive testing of physical and cognitive performance. With Nathan LeBrasseur, he has recently examined the association between systemic markers of senescence (SASP) and aging outcomes. He also leads a study testing whether proteins that mediate benefits of heterochronic parabiosis in mice are associated with beneficial outcomes in older people.

Marco Demaria
Marco Demaria Headshot

Marco Demaria is currently an Associate Professor in Cellular Ageing at the Medical Faculty of the University of Groningen and the Group Leader of the laboratory of Cellular Senescence and Age-related Pathologies of the European Research Institute for the Biology of ageing (ERIBA). He obtained his PhD at the University of Torino, Italy, under the supervision of prof. Valeria Poli. In 2010, he joined the laboratory of prof. Judith Campisi as a postdoctoral fellow at the Buck Institute for Research on Aging in Novato, USA. In 2015, Dr. Demaria returned to Europe and joined the University of Groningen and the European Research Institute for the Biology of Ageing (ERIBA) with a tenure-track position. His work is supported by several agencies and companies. Dr. Demaria serves as Editor in Chief for npj Aging, and as reviewer for several journals and funding agencies. In 2018 he co-founded a start-up company, Cleara Biotech. Since 2022 he is the President of the International Cell Senescence Association (ICSA).

Dr. Demaria is focused towards understanding the molecular basis of aging and age-related disorders, and identifying new molecular and cellular targets to improve health and longevity. At the core of his research is cellular senescence, a potent tumor suppressive mechanism characterized by a strong secretory and pro-inflammatory phenotype. During his postdoctoral studies, he has characterized a new transgenic mouse model for the study of senescence in vivo, and demonstrated that senescent cells accumulate and persist during aging and under genotoxic stress, where they contribute to disease. However, he has also demonstrated that sub-populations of senescent cells cover positive roles during tissue repair.
Now, the goal of the Demaria laboratory is to define the conditions and phenotypes that determine whether a senescent cell covers beneficial or detrimental functions. The laboratory is developing the following projects, with the support of many collaborators and funding schemes:

  • Molecular characterization of the senescence heterogeneity.
  • Role of senescent cells during disease.
  • Clearance of senescent cells.
  • Lifestyle effects on induction of cellular senescence.
  • Pro-senescence therapies to improve tissue repair.
In the long-term, the laboratory aims at developing novel pharmaceutical and nutraceutical interventions to reduce the detriment or improve the benefit of different senescent cells with the goal to improve health and longevity.

Xiao Dong
Xiao Dong Headshot

Dr. Dong obtained his PhD in bioinformatics in the Shanghai Institutes of Biological Sciences at the Chinese Academy of Sciences in 2013. He completed postdoc training in the Department of Genetics at the Albert Einstein College of Medicine in 2021. Since 2021, he started the Dong laboratory in the Institute of the Biology of Aging (iBAM) and the Department of Genetics, Cell Biology and Development (GCD) at the University of Minnesota, Twin Cities. Dr. Dong is interesting in understanding the role of somatic mutations in aging.

The general interest of the Dong Laboratory is discovering causal mechanisms of human aging. Currently, it focuses on testing the mutation theory of aging: if accumulation of DNA mutations in normal somatic cells is a causal mechanism to age-related functional decline. The lab approaches this by developing and applying state-of-the-art single-cell multi-omics technologies and machine learning algorithms.

Vesna Garovic
Vesna Garovic Headshot

Dr. Garovic is Professor of Medicine, Division of Nephrology and Hypertension, Mayo Clinic Rochester, Minnesota, and holds joint appointment in Obstetrics & Gynecology. She currently serves as Chair of Division of Nephrology and Hypertension, Vice-Chair for Research, Department of Internal Medicine, and as Director, Clinical Resaearch and Trials Unit, Mayo Clinic Center for Clinical and Translational Science, Mayo Clinic, Rochester, MN. She has been NIH-funded over the course of 15 years, she serves as a chartered member of the NIH Pregnancy/Neonatology study section (2020-2024), and has published over 200 peer-reviewed papers.

Her clinical and research interests in hypertensive pregnancy disorders and preeclampsia span several research areas: diagnosis and treatment of hypertension in pregnancy, underlying molecular mechanisms, with the most recent focus on senescence, epigenetics, and epidemiology of long-term cardiovascular and renal effects, with the long-term objective of identifying diagnostic biomarkers and potential new therapeutic targets in order to improve immediate and long-term outcomes of this enigmatic disease.

Matthew Gill
Matthew Gill Headshot

Matthew Gill, PhD is an Associate Professor in the Department of Genetics, Cell Biology & Development at the University of Minnesota, Twin Cities Campus. His research lab is part of the Institute on the Biology of Aging & Metabolism and the Medical Discovery Team on the Biology of Aging. His research program has focused on discovering novel signaling pathways and mechanisms through a combination of genetics, drug screening and biochemical approaches. This approach has led to the identification of candidate ligands for an orphan nuclear receptor, an endocannabinoid system in C. elegans and a novel truncated isoform of the nematode insulin receptor.

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